★★★★★ 5.0 - Rated 5.0 out of 5 stars • Based on 4 reviews
*Rating and review count are based on customer reviews published on the manufacturer's website.*

Marini SkinSolutions® Night Zyme® is an advanced overnight resurfacing mask designed to help transform dull, uneven, rough-looking skin into a smoother, more polished, glass-like complexion while you sleep. Its formula combines proteolytic enzyme technology, collagen-supporting peptides, intensive hydrators, botanical oils, and barrier-nourishing ingredients to gently dissolve dead surface proteins, refine texture, soften fine lines, and improve visible pore appearance without relying on aggressive chemical acids.

At the center of the formula is Green Unripened Papaya, a proteolytic enzyme source that helps digest and remove dead surface skin proteins through enzymatic exfoliation. This process helps reveal fresher-looking skin while minimizing the irritation and inflammation that can sometimes accompany more aggressive exfoliating acids. Marini pairs this technology with Acetyl Tetrapeptide-2 and Acetyl Hexapeptide-8, two advanced peptides that support firmness, elasticity, wrinkle smoothing, and a more refined surface appearance.

Night Zyme® is also intentionally hydrating. Shea Butter, Mango Seed Butter, Avocado Oil, Squalane, Polyglutamic Acid, Panthenol, Soybean Sterols, Olive-derived lipids, and humectants help replenish moisture and reinforce barrier comfort overnight. The result is a treatment that resurfaces while simultaneously supporting hydration rather than leaving skin stripped or overly dry.

Marini specifically positions Night Zyme® for concerns including fine lines and wrinkles, volume and laxity, dullness, large-looking pores, and uneven texture, and lists it for combination, dry, and oily skin types.

Size: 1.7 oz.

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Key Benefits

✔️ Provides gentle overnight enzymatic resurfacing

✔️ Helps dissolve dull, dead surface skin proteins

✔️ Promotes a smoother, more polished complexion

✔️ Helps refine the appearance of enlarged pores

✔️ Supports a glass-like skin surface

✔️ Helps soften the appearance of fine lines and wrinkles

✔️ Supports visible firmness and elasticity

✔️ Helps improve overall skin texture

✔️ Provides intensive overnight hydration

✔️ Helps maintain a healthier moisture barrier

✔️ Supports skin softness and suppleness

✔️ Helps calm visible irritation

✔️ Provides antioxidant and botanical skin support

✔️ Resurfaces without relying on aggressive chemical acids

✔️ Designed to be used as the final layer of your nighttime skincare routine

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Key Ingredients & Technologies

Green Unripened Papaya

Proteolytic Enzyme Technology

Green Unripened Papaya is the core resurfacing technology behind Night Zyme®.

Unlike alpha hydroxy acids or beta hydroxy acids, proteolytic enzymes work by helping break down the proteins that hold dull, dead surface cells in place. Marini describes Green Unripened Papaya as providing effective enzymatic exfoliation without irritation while also offering anti-inflammatory benefits.

Benefits:

✔️ Gently dissolves dead surface proteins

✔️ Supports natural enzymatic exfoliation

✔️ Helps improve dullness

✔️ Refines uneven-looking texture

✔️ Helps promote smoother skin

✔️ Helps minimize irritation associated with aggressive resurfacing

✔️ Particularly appealing for skin that does not tolerate stronger acids well

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Acetyl Tetrapeptide-2

Acetyl Tetrapeptide-2 is a specialized peptide designed to support collagen, elastin, skin regeneration, and epidermal recovery.

Marini highlights this peptide for its ability to improve visible firmness and elasticity while helping reduce the appearance of fine lines and wrinkles.

Benefits:

✔️ Supports collagen

✔️ Supports elastin

✔️ Helps improve visible firmness

✔️ Helps improve elasticity

✔️ Supports epidermal recovery

✔️ Helps soften fine lines and wrinkles

✔️ Complements enzymatic resurfacing with structural support

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Acetyl Hexapeptide-8

Neuromodulating Peptide

Acetyl Hexapeptide-8 is a neuromodulating peptide designed to help reduce superficial facial muscle contractions associated with the appearance of expression lines.

Marini specifically notes that it helps smooth the skin and reduce visible pore appearance.

Benefits:

✔️ Helps soften expression lines

✔️ Supports smoother-looking skin

✔️ Helps refine pore appearance

✔️ Supports a more polished skin surface

✔️ Complements the formula’s “glass skin” objective

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Polyglutamic Acid

Polyglutamic Acid is one of Night Zyme’s standout hydrating ingredients.

Marini describes it as a super-hydrator capable of holding up to 5,000 times its weight in water, helping form a moisture-retaining film across the skin and reduce transepidermal water loss.

Benefits:

✔️ Provides intense hydration

✔️ Helps reduce moisture loss

✔️ Supports a smoother-looking surface

✔️ Helps plump visible dehydration lines

✔️ Promotes longer-lasting skin comfort

✔️ Helps balance the resurfacing action of the enzymes

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Shea Butter

Shea Butter provides rich emollient and barrier-supportive benefits.

Marini highlights Shea Butter for its beneficial fatty acids, Vitamins A and E, moisturizing properties, and anti-inflammatory support.

Benefits:

✔️ Deeply moisturizes

✔️ Supports the skin barrier

✔️ Helps soften dry or damaged skin

✔️ Provides antioxidant support

✔️ Helps maintain comfort overnight

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Mango Seed Butter

Mango Seed Butter is a rich, creamy botanical butter high in stearic and oleic acids that helps support moisturization and barrier integrity.

Benefits:

✔️ Provides intensive moisture

✔️ Supports barrier function

✔️ Helps soften rough texture

✔️ Provides antioxidant support

✔️ Non-comedogenic profile

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Avocado Oil

Avocado Oil provides a nutrient-rich blend of omega fatty acids and Vitamins A, D, and E.

Marini incorporates it to help deeply moisturize dry or damaged skin while supporting barrier repair and long-lasting emollient benefits.

Benefits:

✔️ Helps replenish lipids

✔️ Supports barrier repair

✔️ Helps improve suppleness

✔️ Provides long-lasting nourishment

✔️ Supports dry and compromised skin

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Squalane

Squalane is a lightweight, skin-compatible emollient that mimics components found naturally within the skin.

It helps provide moisturization without excessive greasiness while supporting barrier function and suppleness.

Benefits:

✔️ Provides lightweight moisture

✔️ Supports barrier integrity

✔️ Helps soften skin

✔️ Improves suppleness

✔️ Suitable across multiple skin types

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Soybean Sterols

Soybean Sterols provide essential fatty acids, antioxidant support, and barrier-conditioning benefits.

Marini highlights soybean-derived ingredients for helping maintain skin suppleness while supporting healthy skin-aging processes.

Benefits:

✔️ Supports barrier function

✔️ Helps maintain skin flexibility

✔️ Provides antioxidant protection

✔️ Helps improve overall moisture balance

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Olive Extract

Olive-derived lipids and extracts provide fatty acids, squalene, Vitamin E, and polyphenols to support hydration and environmental defense.

Benefits:

✔️ Helps moisturize

✔️ Supports barrier health

✔️ Provides antioxidant support

✔️ Helps protect against environmental stress

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Echinacea Extract

Echinacea Purpurea Extract provides soothing, antioxidant, and skin-defense support.

Marini describes it as helping strengthen the skin’s natural defenses while calming stressed or compromised skin.

Benefits:

✔️ Helps calm stressed skin

✔️ Provides antioxidant protection

✔️ Supports skin resilience

✔️ Helps maintain overall skin health

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Alpha-Bisabolol

Bisabolol is a soothing compound traditionally derived from chamomile and included for its anti-inflammatory properties.

Marini highlights it for helping calm sensitive or irritated skin.

Benefits:

✔️ Helps calm visible irritation

✔️ Supports sensitive skin

✔️ Helps improve skin tolerance

✔️ Complements resurfacing ingredients

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Allantoin

Allantoin provides soothing, moisturizing, and skin-renewing support.

Marini notes that it helps promote cell regeneration, reduce irritation, and improve skin texture.

Benefits:

✔️ Helps soothe skin

✔️ Supports healthy renewal

✔️ Helps improve texture

✔️ Provides moisturizing support

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Panthenol

Vitamin B5

Panthenol helps support hydration, barrier function, and skin recovery.

Benefits:

✔️ Helps improve moisture retention

✔️ Supports barrier function

✔️ Helps calm irritation

✔️ Supports softer, healthier-looking skin

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How to Use

Complete your normal evening skincare routine.

Apply your cleanser, serums, corrective products, and moisturizer as usual.

Then apply Marini SkinSolutions® Night Zyme® as the final layer over all of your PM skincare products.

Leave on overnight.

Cleanse the skin normally the following morning.

Use consistently in the evening according to your skin’s tolerance and professional skincare recommendations.

Because Night Zyme® is an enzymatic resurfacing treatment, daily broad-spectrum sunscreen remains essential.

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Where It Fits in Your Routine

Night Zyme® is specifically designed to be your final nighttime skincare step.

Evening

1. Cleanser
2. Antioxidant or treatment serum
3. Corrective treatment
4. Hydrator or moisturizer
5. Marini SkinSolutions® Night Zyme®

Marini explicitly instructs users to apply Night Zyme® as the final layer over all PM routine products.

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Ideal For

Dull or lackluster skin

Uneven skin texture

Visible pores

Fine lines and wrinkles

Loss of smoothness

Loss of firmness

Loss of elasticity

Volume and laxity concerns

Dry skin

Combination skin

Oily skin

Skin that cannot tolerate strong chemical exfoliants

Individuals seeking enzymatic resurfacing

Clients seeking a glass-skin appearance

Those wanting smoother skin without aggressive acids

Marini specifically lists the product for Fine Lines & Wrinkles and Volume & Laxity, and identifies it as suitable for combination, dry, and oily skin.

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Professional Insight

Night Zyme® is particularly interesting because it approaches resurfacing differently from the acid-based exfoliants most people associate with smoother skin.

The goal is still the same: remove the dull, dead surface buildup that can make the complexion appear rough, uneven, and less reflective.

But instead of relying primarily on glycolic acid, lactic acid, salicylic acid, or another chemical exfoliant, Night Zyme® uses proteolytic enzyme technology derived from Green Unripened Papaya.

Proteolytic enzymes target proteins.

At the skin surface, those enzymes help digest the proteins associated with accumulated dead cells, allowing them to release more naturally. The result is a smoother-looking complexion without necessarily producing the aggressive exfoliating response some clients experience with stronger acids.

That distinction can be especially valuable for skin that needs resurfacing but doesn’t tolerate aggressive chemical exfoliation well.

Marini specifically describes the Green Unripened Papaya enzyme as providing effective exfoliation without irritation or inflammation, which is a major reason Night Zyme® stands apart within the resurfacing category.

But enzymatic exfoliation is only one part of the formula.

What makes Night Zyme® much more sophisticated is that Marini surrounds its resurfacing technology with peptides and hydration.

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Resurfacing + Peptides + Hydration

This is the combination that really defines Night Zyme®.

Step 1: Resurface

Green Unripened Papaya enzymes help digest dull surface proteins and improve visible skin texture.

Step 2: Smooth and Firm

Acetyl Tetrapeptide-2 helps support collagen, elastin, firmness, and elasticity.

Acetyl Hexapeptide-8 helps address superficial facial contractions that contribute to expression lines while improving visible pore appearance.

Step 3: Rehydrate

Polyglutamic Acid, Shea Butter, Mango Seed Butter, Avocado Oil, Squalane, Panthenol, and other emollients help restore moisture and support the skin barrier.

That third step matters because exfoliation without adequate hydration can sometimes make the skin temporarily look drier or emphasize fine lines.

Night Zyme® is designed to do the opposite.

It resurfaces while simultaneously replenishing moisture.

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Why “Glass Skin” Makes Sense Here

The term “glass skin” gets used frequently, but visually it refers to something very specific: skin that looks exceptionally smooth, hydrated, even, and reflective.

Light reflects most evenly from a smooth surface.

If dead skin buildup, dehydration, visible pores, or rough texture are disrupting the surface, light scatters more unevenly and the complexion can look dull.

Night Zyme® tackles several of those issues simultaneously.

The enzymes improve surface smoothness.

The peptides help refine lines and structural appearance.

The hydration ingredients help plump and soften the complexion.

The result is a more uniform surface that reflects light more evenly and therefore appears more polished and luminous.

Marini specifically describes the goal as an “ultra polished, glass-like skin surface” with consistent PM use.

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A Smart Option for Clients Already Using Active Products

Another thing we like about Night Zyme® is where it sits within the routine.

Marini doesn't position it as a replacement for your serums, corrective products, or moisturizer.

You apply those products first.

Then Night Zyme® goes over everything as the final overnight layer.

That makes it a very easy addition to an established skincare routine.

For someone already using a sophisticated Marini regimen, there is no need to rebuild the entire evening routine. Night Zyme® simply becomes the finishing treatment.

This final-layer format also allows the moisturizing components to help seal in the products underneath while the enzymes work on the skin surface overnight.

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Professional Recommendation

Marini SkinSolutions® Night Zyme® is especially beneficial for:

✔️ Dull, lackluster skin

✔️ Rough or uneven texture

✔️ Enlarged-looking pores

✔️ Fine lines and wrinkles

✔️ Loss of surface smoothness

✔️ Loss of firmness and elasticity

✔️ Volume and laxity concerns

✔️ Dry skin needing resurfacing

✔️ Combination skin

✔️ Oily skin

✔️ Clients seeking enzymatic rather than aggressive acid exfoliation

✔️ Individuals wanting overnight resurfacing

✔️ Clients seeking a polished “glass skin” appearance

✔️ Individuals whose skin looks congested or dull from surface buildup

✔️ Clients seeking peptide + resurfacing technology

✔️ Anyone wanting an easy final-step nighttime treatment

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Formulation Highlights

✔️ Proteolytic Enzyme Technology

✔️ Green Unripened Papaya

✔️ Acetyl Tetrapeptide-2

✔️ Acetyl Hexapeptide-8

✔️ Polyglutamic Acid

✔️ Shea Butter

✔️ Mango Seed Butter

✔️ Avocado Oil

✔️ Squalane

✔️ Panthenol / Vitamin B5

✔️ Soybean Sterols

✔️ Olive-Derived Lipids

✔️ Echinacea Extract

✔️ Bisabolol

✔️ Allantoin

✔️ Tocopherol / Vitamin E

✔️ Glycerin

✔️ Saccharide Isomerate

✔️ Overnight Enzymatic Resurfacing

✔️ Peptide Firming Support

✔️ Pore-Refining Benefits

✔️ Intensive Hydration

✔️ Barrier Support

✔️ Glass-Skin Smoothing Technology

✔️ Alcohol (Ethanol) Free

✔️ BHA Free

✔️ BHT Free

✔️ Formaldehyde Free

✔️ Paraben Free

✔️ Phthalate Free

✔️ Vegan

✔️ Never Tested on Animals

✔️ Made in the USA

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With consistent evening use, Marini SkinSolutions® Night Zyme® Overnight Glass Skin Resurfacing Complex helps transform dull, rough, uneven-looking skin through a sophisticated combination of Green Unripened Papaya proteolytic enzymes, Acetyl Tetrapeptide-2, Acetyl Hexapeptide-8, Polyglutamic Acid, Shea Butter, Mango Seed Butter, Avocado Oil, Squalane, and soothing botanicals.

What makes Night Zyme® especially appealing is its balance: it delivers meaningful overnight resurfacing without relying on aggressive acids, while peptides help address firmness, elasticity, expression lines, and visible pores and intensive hydrators help keep the skin comfortable and supple.

For clients working toward a smoother, brighter, more refined, glass-like complexion, Night Zyme® is an excellent final nighttime treatment—simply apply it over the rest of the evening regimen and allow the enzymes, peptides, and moisture-supporting ingredients to work while you sleep.