★★★★★ 5.0 - Rated 5.0 out of 5 stars • Based on 13 reviews
*Rating and review count are based on customer reviews published on the manufacturer's website.*

Marini SkinSolutions® NeuroSmooth® is an advanced, multi-faceted neuropeptide serum designed to create an ultra-smooth, refined, more uniform “glass skin” complexion while addressing visible pores, fine lines, wrinkles, uneven texture, redness, and loss of firmness. Its sophisticated formula combines neuromodulating peptides, collagen-supporting peptides, soothing technologies, antioxidants, and post-procedure recovery ingredients to improve skin quality from multiple angles.

Unlike traditional smoothing serums that primarily rely on exfoliation or resurfacing acids, NeuroSmooth® targets another contributor to uneven-looking skin: superficial micro-muscular contractions. Marini SkinSolutions explains that these contractions, combined with collagen loss, can increase the visible appearance of pores and interfere with the smooth, reflective surface associated with luminous “glass skin.”

The formula features an impressive peptide complex including Acetyl Hexapeptide-8, Acetyl Tetrapeptide-2, Tripeptide-56, sh-Oligopeptide-4 (Thymosin Beta-4), Palmitoyl Tetrapeptide-7, and Dipeptide-2, together with Kangaroo Paw Extract, Hesperidin Methyl Chalcone, Vitamin K1 Oxide, Arnica Montana Extract, Sodium Hyaluronate, Allantoin, and barrier-conditioning ingredients.

NeuroSmooth® is also specifically designed to complement professional injectable treatments. Marini positions it as an excellent standalone treatment as well as a needle-free companion to injectable procedures, where it can help address visible texture, pore appearance, redness, bruising, and overall skin quality—areas that injectables alone may not fully address.

Size: 1 oz.

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Key Benefits

✔️ Helps create a smoother, more refined “glass skin” appearance

✔️ Visibly reduces the appearance of enlarged pores

✔️ Helps soften the appearance of fine lines and wrinkles

✔️ Targets superficial micro-muscular contractions

✔️ Supports healthy collagen and elastin

✔️ Helps improve visible skin firmness

✔️ Refines uneven skin texture

✔️ Promotes a more luminous, reflective complexion

✔️ Helps improve overall skin tone uniformity

✔️ Helps calm visible redness

✔️ Supports post-procedure skin recovery

✔️ Helps reduce the visible appearance of bruising following procedures

✔️ Supports healthier-looking skin repair

✔️ Provides antioxidant protection

✔️ Helps improve overall skin quality

✔️ Excellent as a standalone daily treatment

✔️ Specifically designed to complement injectable procedures

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Key Ingredients & Technologies

Acetyl Hexapeptide-8

Neuromodulating Peptide

Acetyl Hexapeptide-8 is one of the signature ingredients behind the NeuroSmooth® concept.

According to Marini SkinSolutions, this peptide targets the SNARE complex, helping reduce neurotransmitter release associated with superficial facial muscle contractions. By helping minimize these repetitive micro-contractions, the peptide can contribute to smoother-looking skin and reduced visible wrinkle and pore appearance.

Benefits:

✔️ Helps reduce superficial micro-muscular contractions

✔️ Helps soften expression lines

✔️ Supports smoother-looking skin

✔️ Helps reduce visible pore appearance

✔️ Promotes a more refined skin surface

✔️ Supports the “glass skin” effect

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Acetyl Tetrapeptide-2

Collagen + Elastin Support

Acetyl Tetrapeptide-2 is a specialized peptide designed to support several processes associated with healthy-looking skin structure.

Marini highlights its ability to support collagen, elastin, skin regeneration, and epidermal recovery, helping improve visible firmness and elasticity while reducing the appearance of fine lines and wrinkles.

Benefits:

✔️ Supports collagen

✔️ Supports elastin

✔️ Helps improve visible firmness

✔️ Supports epidermal recovery

✔️ Helps improve elasticity

✔️ Helps soften fine lines and wrinkles

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Tripeptide-56

Tripeptide-56 is a specialized peptide designed to work through targeted cellular pathways and communication mechanisms to improve visible skin condition.

Marini specifically highlights its ability to help reduce the appearance of vertical wrinkles, including areas such as frown lines and marionette lines.

Benefits:

✔️ Helps improve visible wrinkles

✔️ Targets vertical-looking lines

✔️ Supports smoother skin texture

✔️ Helps improve overall skin quality

✔️ Complements the formula's neuromodulating peptide technology

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Thymosin Beta-4

sh-Oligopeptide-4

Thymosin Beta-4 is a cell-regenerating peptide that supports processes associated with tissue repair and recovery.

Marini describes it as helping promote cell migration and differentiation, supporting wound-healing processes and enhancing visible skin recovery.

This makes it especially relevant to NeuroSmooth's post-procedure positioning.

Benefits:

✔️ Supports healthy skin repair

✔️ Promotes visible recovery

✔️ Helps soothe stressed skin

✔️ Supports smoother-looking skin

✔️ Helps improve visible firmness

✔️ Provides hydrating and calming support

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Palmitoyl Tetrapeptide-7

Palmitoyl Tetrapeptide-7 provides additional collagen and soothing support.

Marini states that this peptide helps reduce secretion of interleukin-6 (IL-6), helping address inflammation and collagen degradation while supporting improvements in wrinkle depth, skin density, and elasticity.

Benefits:

✔️ Helps calm visible inflammation

✔️ Supports collagen preservation

✔️ Helps improve visible wrinkle depth

✔️ Supports skin density

✔️ Helps improve elasticity

✔️ Promotes healthier-looking skin

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Dipeptide-2

Dipeptide-2 provides circulation-related support and is frequently incorporated into advanced formulations targeting visible puffiness.

Marini describes it as supporting lymphatic circulation and helping reduce the appearance of fluid retention and puffiness.

Benefits:

✔️ Supports lymphatic circulation

✔️ Helps address visible puffiness

✔️ Supports a more rested appearance

✔️ Complements the formula's recovery technologies

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Kangaroo Paw Extract

Anigozanthos Flavidus Extract

Kangaroo Paw Extract is an Australian botanical rich in phenolic compounds and antioxidants.

Marini incorporates it for its ability to help protect against environmental stress while supporting collagen, elastin, firmness, lifting, hydration, and visible smoothness.

Benefits:

✔️ Supports collagen and elastin

✔️ Helps improve visible firmness

✔️ Supports a lifted-looking complexion

✔️ Provides antioxidant protection

✔️ Helps soothe skin

✔️ Supports hydration

✔️ Helps soften visible lines and wrinkles

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Hesperidin Methyl Chalcone

Hesperidin Methyl Chalcone is a flavonoid derivative with antioxidant and soothing properties that also supports healthy microcirculation.

Benefits:

✔️ Provides antioxidant protection

✔️ Helps calm visible redness

✔️ Supports healthy microcirculation

✔️ Helps improve the appearance of puffiness

✔️ Supports more even-looking skin

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Vitamin K1 Oxide

Phytonadione Epoxide

Vitamin K technology adds an important post-procedure dimension to NeuroSmooth®.

Marini highlights Vitamin K for supporting capillary health and helping reduce the visible appearance of bruising and circulation-related discoloration.

Benefits:

✔️ Supports capillary health

✔️ Helps improve visible bruising

✔️ Supports post-procedure recovery

✔️ Helps improve circulation-related skin concerns

✔️ Complements Arnica and Hesperidin

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Arnica Montana Extract

Arnica Montana Flower Extract is particularly relevant for clients incorporating NeuroSmooth® around professional aesthetic treatments.

The botanical has traditionally been used for its soothing and circulation-supporting properties, and Marini includes it to help reduce the appearance of bruising and inflammation while supporting skin recovery.

Benefits:

✔️ Helps reduce visible bruising

✔️ Helps calm visible inflammation

✔️ Supports post-procedure recovery

✔️ Helps soothe stressed-looking skin

✔️ Complements Vitamin K technology

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Sodium Hyaluronate

A form of Hyaluronic Acid, Sodium Hyaluronate provides hydration to support the smooth, plump appearance that is essential to the “glass skin” effect. It is included in the current NeuroSmooth® formulation.

Benefits:

✔️ Helps increase hydration

✔️ Supports visible plumpness

✔️ Helps soften dehydration lines

✔️ Promotes smoother-looking texture

✔️ Supports overall skin comfort

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How to Use

Shake well before use.

Apply sparingly to the entire face.

Use morning and evening.

Follow with an appropriate hydrator or moisturizer.

During the day, always finish with broad-spectrum sunscreen.

When incorporating NeuroSmooth® into the complete Marini SkinSolutions® Skin Care Management System™, the manufacturer recommends using it as an accelerator after Step 3: Bioclear® Face Lotion/Cream and before your hydrator.

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Where It Fits in Your Routine

NeuroSmooth® is an advanced treatment serum/accelerator that can be incorporated into both morning and evening routines.

Morning

1. Cleanser
2. Antioxidant/Vitamin C Treatment
3. Corrective Treatment
4. Marini SkinSolutions® NeuroSmooth®
5. Hydrator/Moisturizer
6. Broad-Spectrum SPF

Evening

1. Cleanser
2. Treatment Serum
3. Corrective Treatment
4. Marini SkinSolutions® NeuroSmooth®
5. Hydrator/Moisturizer

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Ideal For

Fine lines and wrinkles

Visible pores

Uneven skin texture

Loss of smoothness

Loss of firmness

Loss of elasticity

Volume and laxity concerns

Redness

Post-procedure skin

Post-injectable skincare

Visible bruising

Dull or lackluster skin

Clients seeking a “glass skin” appearance

Individuals seeking advanced peptide technology

Mature skin

Combination skin

Dry skin

Oily skin

Marini SkinSolutions specifically identifies NeuroSmooth® for Fine Lines & Wrinkles, Volume & Laxity, Redness, and Post-Procedure concerns, and lists it for combination, dry, and oily skin.

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Professional Insight

NeuroSmooth® is a particularly interesting addition to a professional skincare regimen because it addresses something that most conventional serums don't directly target: the relationship between superficial micro-muscular contractions, collagen loss, pore appearance, and skin smoothness.

When we think about “glass skin,” we often focus entirely on hydration.

Hydration certainly matters, but truly smooth, reflective-looking skin depends on several factors: pore appearance, texture, firmness, inflammation, hydration, collagen support, and the uniformity of the skin's surface.

NeuroSmooth® approaches all of these simultaneously.

Its signature Acetyl Hexapeptide-8 is a neuromodulating peptide designed to help reduce superficial micro-muscular contractions.

This is why you'll sometimes hear this category of cosmetic peptide described informally as producing a “Botox-like” effect. However, that description can be misleading.

NeuroSmooth® is not Botox, and topical peptides are not a substitute for injectable neuromodulators.

Instead, NeuroSmooth® provides a topical cosmetic strategy for helping soften the appearance of expression-related lines and create a smoother-looking skin surface.

And that distinction actually leads to one of the most compelling aspects of this product:

NeuroSmooth® was designed to work beautifully WITH injectables—not necessarily instead of them.

Marini specifically positions NeuroSmooth® as an excellent standalone treatment and as a companion to injectable procedures.

Injectable neuromodulators can address deeper muscular movement, but they don't necessarily correct visible pores, uneven texture, redness, bruising, hydration, or overall skin quality.

NeuroSmooth® targets those complementary concerns.

That makes the combination particularly compelling for clients who invest in professional aesthetic procedures but want the surface quality of their skin to look as refined as the underlying facial structure.

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Why the Peptide Combination Matters

Another reason NeuroSmooth® stands apart is that Marini didn't formulate it around one “hero” peptide.

It contains a sophisticated network of peptides with different functions:

Acetyl Hexapeptide-8 – neuromodulating support.

Acetyl Tetrapeptide-2 – collagen, elastin, firmness, and epidermal recovery.

Tripeptide-56 – visible wrinkle support.

Thymosin Beta-4 – cellular repair and recovery.

Palmitoyl Tetrapeptide-7 – soothing and collagen support.

Dipeptide-2 – circulation and puffiness support.

This creates a multi-pathway approach rather than asking one peptide to accomplish everything.

The supporting ingredients are equally purposeful.

Kangaroo Paw Extract supports collagen, elastin, firmness, and antioxidant protection.

Hesperidin Methyl Chalcone supports microcirculation and visible redness.

Vitamin K1 Oxide supports bruising-related concerns.

Arnica Montana helps soothe visible inflammation and bruising.

Sodium Hyaluronate provides hydration.

This is why NeuroSmooth® makes sense not only as a wrinkle serum, but as a skin-quality serum.

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Especially Impressive for Injectable Clients

The post-procedure component deserves particular attention.

Many clients who receive injectable treatments experience temporary redness, swelling, bruising, or general skin disruption.

NeuroSmooth® combines several ingredients specifically selected to support this recovery period, including Thymosin Beta-4, Hesperidin Methyl Chalcone, Vitamin K1 Oxide, Arnica Montana, Palmitoyl Tetrapeptide-7, and Dipeptide-2.

Marini reports that NeuroSmooth® supports redness and bruising after injection while improving aspects of skin quality that injectable treatments don't directly address.

For someone already investing in professional treatments, that's an appealing concept: use injectables to address their intended structural or muscular target while using NeuroSmooth® to improve the visible quality, texture, smoothness, and uniformity of the skin itself.

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Clinical Study Results

The clinical results reported by Marini SkinSolutions® are especially noteworthy.

In one two-month study:

✔️ 100% of subjects were satisfied with product results

✔️ 100% reported improvement in one or more areas of concern, including skin quality, fine lines, texture, redness, and pore size

✔️ 91% reported improvement in both pore size and texture

In another two-month study:

✔️ 94% of subjects showed improvement in one or more concerns, including pore size, texture, skin quality, and redness

✔️ 92% of injectable procedures were reported to have enhanced overall results when NeuroSmooth® was incorporated

Marini notes that subjects demonstrated significant improvement both with and without injectable treatments, making NeuroSmooth® relevant even for individuals who don't receive injectables.

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Professional Recommendation

Marini SkinSolutions® NeuroSmooth® is especially beneficial for:

✔️ Fine lines and wrinkles

✔️ Expression-related lines

✔️ Enlarged-looking pores

✔️ Uneven skin texture

✔️ Loss of smoothness

✔️ Loss of firmness

✔️ Loss of elasticity

✔️ Redness-prone skin

✔️ Dull or uneven-looking complexions

✔️ Clients seeking a glass-skin appearance

✔️ Mature skin

✔️ Post-procedure skincare

✔️ Post-injectable recovery

✔️ Visible bruising following aesthetic procedures

✔️ Clients receiving neuromodulator injections

✔️ Clients receiving injectable aesthetic treatments

✔️ Individuals seeking advanced peptide technology

✔️ Clients wanting improved overall skin quality

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Formulation Highlights

✔️ Advanced Neuromodulating Peptide Technology

✔️ Acetyl Hexapeptide-8

✔️ Acetyl Tetrapeptide-2

✔️ Tripeptide-56

✔️ sh-Oligopeptide-4 / Thymosin Beta-4

✔️ Palmitoyl Tetrapeptide-7

✔️ Dipeptide-2

✔️ Kangaroo Paw Extract

✔️ Hesperidin Methyl Chalcone

✔️ Vitamin K1 Oxide

✔️ Arnica Montana Flower Extract

✔️ Sodium Hyaluronate

✔️ Allantoin

✔️ Glycerin

✔️ Shea Butter

✔️ Neuromodulating Peptide Support

✔️ Collagen + Elastin Support

✔️ Pore-Refining Benefits

✔️ Texture-Smoothing Benefits

✔️ Redness Support

✔️ Post-Procedure Recovery Support

✔️ Bruising Support

✔️ Antioxidant Protection

✔️ Hydration Support

✔️ Alcohol (Ethanol) Free

✔️ BHA Free

✔️ BHT Free

✔️ Dye Free

✔️ Formaldehyde Free

✔️ Fragrance Free

✔️ Paraben Free

✔️ PEG Free

✔️ Phthalate Free

✔️ Sulfate Free

✔️ Vegan

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With consistent morning and evening use, Marini SkinSolutions® NeuroSmooth® provides a sophisticated, multi-pathway approach to achieving smoother, more refined, luminous-looking skin. Its combination of neuromodulating peptides, collagen-supporting peptides, regenerative technologies, antioxidants, circulation-supporting ingredients, and post-procedure recovery agents helps address pore appearance, fine lines, wrinkles, uneven texture, redness, firmness, and overall skin quality.

For clients seeking the highly polished, reflective appearance associated with “glass skin,” NeuroSmooth® is particularly compelling because it goes beyond hydration and exfoliation. By addressing superficial micro-muscular contractions while simultaneously supporting collagen, elasticity, recovery, redness, hydration, and skin texture, it targets many of the individual factors that determine how smooth and luminous the skin ultimately appears.

And for clients receiving professional injectables, NeuroSmooth® offers an especially interesting complement: injectables can address their intended muscular or structural concerns, while NeuroSmooth® helps refine the visible quality of the skin itself—supporting smoother texture, smaller-looking pores, reduced redness, recovery, and a more polished overall complexion.