★★★★★ 4.8 - Rated 4.8 out of 5 stars • Based on 222 reviews
*Rating and review count are based on customer reviews published on the manufacturer's website.*

HydroPeptide® Collagen ReActivate PM is a best-selling nighttime treatment moisturizer designed to maximize visible collagen support while improving the appearance of fine lines, wrinkles, uneven texture, dullness, dehydration, firmness, and elasticity. Powered by proprietary NIMNI™ Technology, this luxurious cream delivers the concentrated performance of a treatment serum while helping restore smoother, fuller, more resilient-looking skin overnight.

At the center of the formula is a proprietary blend of amino acids and antioxidants clinically studied to optimize the collagen production process. HydroPeptide pairs this technology with biomimetic peptides, 0.25% time-release retinol, ELLAGI-C™, and Vitamin C to support healthy cell turnover, collagen synthesis, antioxidant defense, and a more even-looking complexion.

What makes Collagen ReActivate PM especially compelling is its ability to combine retinol-based renewal with a broader collagen-supportive system. Rather than relying on retinol alone, it surrounds the ingredient with peptides, amino acids, antioxidants, ceramides, squalane, and nourishing lipids to create a comprehensive overnight treatment.

In a clinical study published in the Journal of Drugs in Dermatology, 91% of participants showed a diminished appearance of fine lines and wrinkles and smoother texture after eight weeks.

Size: 1 fl oz / 30 mL

Cruelty-Free • Vegan • Gluten-Free • Sulfate-Free • Phthalate-Free • Paraben-Free

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Key Benefits

✔️ Helps soften the appearance of fine lines and wrinkles

✔️ Supports visible collagen production

✔️ Helps improve skin firmness and elasticity

✔️ Promotes smoother, more refined-looking texture

✔️ Helps restore the appearance of youthful fullness

✔️ Encourages healthy nighttime cell turnover

✔️ Helps brighten dull, uneven-looking skin

✔️ Supports a more even complexion

✔️ Provides antioxidant protection

✔️ Helps strengthen and protect the skin

✔️ Combines retinol with advanced peptide technology

✔️ Delivers intensive age-supporting benefits in a luxurious nighttime moisturizer

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Real Skin. Real Results.

After 8 weeks:

91% of participants showed a diminished appearance of fine lines and wrinkles and smoother skin texture.

HydroPeptide notes that the efficacy and safety of Collagen ReActivate PM were evaluated in a clinical trial published in the Journal of Drugs in Dermatology.

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Key Ingredients

NIMNI™ Technology

NIMNI™ Technology is HydroPeptide's proprietary blend of amino acids and antioxidants, clinically studied to help optimize the collagen production process.

Benefits:

✔️ Supports healthy collagen production

✔️ Helps improve the appearance of firmness

✔️ Supports fuller-looking skin

✔️ Helps improve elasticity

✔️ Promotes smoother, more youthful-looking skin

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0.25% Time-Release Retinol

Collagen ReActivate PM contains 0.25% time-release retinol, designed to support healthy cell turnover and collagen production while helping minimize the inflammatory response sometimes associated with conventional retinol delivery.

Benefits:

✔️ Encourages healthy skin renewal

✔️ Helps smooth uneven texture

✔️ Supports collagen production

✔️ Helps soften fine lines and wrinkles

✔️ Promotes a brighter, more refined complexion

✔️ Provides gradual nighttime retinol delivery

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Biomimetic Peptides

HydroPeptide highlights SYN®-TC and Neodermyl as structural-integrity peptide technologies designed to signal skin cells to support collagen production for firmer, plumper-looking skin.

Benefits:

✔️ Supports firmer-looking skin

✔️ Helps improve visible plumpness

✔️ Complements collagen production

✔️ Supports skin structural integrity

✔️ Helps address visible loss of elasticity

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ELLAGI-C™

ELLAGI-C™ is a tree bark extract used to help enhance the stability and effectiveness of Vitamin C while reducing oxidative stress and supporting a more even-looking complexion.

Benefits:

✔️ Helps reduce oxidative stress

✔️ Supports brighter-looking skin

✔️ Helps improve uneven pigmentation

✔️ Complements collagen-supportive ingredients

✔️ Enhances the formula's antioxidant strategy

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Vitamin C

Vitamin C helps protect against free radicals while supporting brighter, more even-looking skin and healthy collagen.

Benefits:

✔️ Provides antioxidant protection

✔️ Helps brighten dull skin

✔️ Supports healthy collagen

✔️ Helps improve uneven tone

✔️ Supports overall skin radiance

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Ceramide NP

Ceramide NP appears in the current formula and helps support the skin's moisture barrier.

Benefits:

✔️ Helps reinforce barrier function

✔️ Supports moisture retention

✔️ Helps improve skin comfort

✔️ Complements retinol-based treatment

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Squalane, Shea Butter & Sunflower Seed Oil

The formula incorporates Squalane, Shea Butter, and Sunflower Seed Oil to provide nourishing lipid support and help maintain comfortable hydration overnight.

Benefits:

✔️ Helps nourish dry skin

✔️ Supports barrier health

✔️ Promotes softness and suppleness

✔️ Helps offset dryness associated with retinol use

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How to Use

Use in the evening on clean, dry skin.

Apply your toner or essence first, followed by compatible treatment serums.

Apply a small amount of HydroPeptide® Collagen ReActivate PM evenly over the face and neck.

Gently massage into the skin until absorbed.

Because this product contains retinol, introduce it gradually if your skin is new to retinoids.

During the following day, always apply a broad-spectrum sunscreen.

If you are already using additional retinoids, strong exfoliating acids, or intensive resurfacing products, avoid unnecessarily combining them in the same routine unless recommended by your skincare professional.

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Where It Fits in Your Routine

Collagen ReActivate PM is your nighttime treatment moisturizer and should generally be used after serums as the final major treatment step.

Evening

1. Cleanser
2. Toner or Essence
3. Compatible Treatment Serum(s)
4. Eye Treatment
5. HydroPeptide® Collagen ReActivate PM

Morning After Use

1. Cleanser
2. Toner or Essence
3. Treatment Serum(s)
4. Moisturizer
5. Broad-Spectrum SPF

For a complete day-and-night collagen regimen, pair Collagen ReActivate PM with Collagen ReActivate AM in the morning.

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Ideal For

Fine lines and wrinkles

Uneven skin texture

Uneven skin tone

Dull skin

Dehydrated skin

Loss of firmness

Loss of elasticity

Visible collagen decline

Mature skin

Early and advanced signs of aging

Individuals seeking retinol-based nighttime skincare

Clients seeking advanced peptide technology

Individuals wanting collagen-focused overnight treatment

HydroPeptide specifically identifies uneven texture and tone, dullness and dehydration, and all signs of skin aging as primary concerns for Collagen ReActivate PM.

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Professional Insight

Collagen decline is one of the most important contributors to visible skin aging. As natural collagen production slows, the skin can gradually lose firmness, elasticity, fullness, and smoothness. Fine lines become more noticeable, texture changes, and the complexion may appear thinner or less resilient.

HydroPeptide® Collagen ReActivate PM addresses this by combining several complementary strategies rather than relying on a single active ingredient.

The foundation is NIMNI™ Technology, which provides a proprietary blend of amino acids and antioxidants designed to support the collagen production process. This is paired with SYN®-TC and Neodermyl biomimetic peptides, which help signal processes associated with collagen production and structural support.

Then comes 0.25% time-release retinol.

Retinol remains one of the most established ingredients for visible skin renewal because it helps encourage cell turnover while supporting collagen. The time-release delivery system used here is particularly valuable because it provides gradual exposure rather than delivering the full amount at once, helping support results while improving tolerability.

That makes Collagen ReActivate PM different from a basic retinol cream. Retinol is only one component of a broader regenerative strategy.

ELLAGI-C™ and Vitamin C provide antioxidant and brightening support, while Ceramide NP, Squalane, Shea Butter, Sunflower Seed Oil, phospholipids, and linoleic acid help maintain moisture and barrier comfort.

This combination is especially important because successful retinol use depends heavily on maintaining barrier health. A formula that supports hydration and lipids can help make consistent nighttime use more comfortable.

The clinical results are equally compelling. After eight weeks, 91% of participants demonstrated a diminished appearance of fine lines and wrinkles and smoother texture.

For clients seeking an advanced nighttime treatment that addresses wrinkles, texture, firmness, elasticity, dullness, dehydration, and collagen support simultaneously, Collagen ReActivate PM is one of HydroPeptide's most comprehensive age-supporting moisturizers.

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Professional Recommendation

HydroPeptide® Collagen ReActivate PM is especially beneficial for:

✔️ Fine lines and wrinkles

✔️ Loss of firmness

✔️ Decreased elasticity

✔️ Uneven skin texture

✔️ Uneven skin tone

✔️ Dull or tired-looking skin

✔️ Dehydrated skin

✔️ Mature skin

✔️ Visible collagen decline

✔️ Individuals beginning or maintaining a retinol regimen

✔️ Clients seeking peptide + retinol technology

✔️ Individuals wanting intensive nighttime skin renewal

✔️ Those pairing it with Collagen ReActivate AM

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Formulation Highlights

✔️ NIMNI™ Technology

✔️ 0.25% Time-Release Retinol

✔️ SYN®-TC

✔️ Neodermyl

✔️ ELLAGI-C™

✔️ Vitamin C

✔️ Tetrahexyldecyl Ascorbate

✔️ Carnosine

✔️ Ceramide NP

✔️ Squalane

✔️ Shea Butter

✔️ Sunflower Seed Oil

✔️ Linoleic Acid

✔️ Phospholipids

✔️ Amino Acid Complex

✔️ Advanced Biomimetic Peptides

✔️ Collagen-Supportive Technology

✔️ Nighttime Resurfacing Support

✔️ Cruelty-Free

✔️ Vegan

✔️ Gluten-Free

✔️ Sulfate-Free

✔️ Phthalate-Free

✔️ Paraben-Free

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With consistent evening use, HydroPeptide® Collagen ReActivate PM Lifting Treatment Moisturizer + Retinol helps visibly improve fine lines, wrinkles, firmness, elasticity, texture, and overall skin quality through a sophisticated combination of NIMNI™ Technology, 0.25% time-release retinol, biomimetic peptides, ELLAGI-C™, Vitamin C, ceramides, and nourishing lipids.

For clients looking for more than a traditional retinol moisturizer, Collagen ReActivate PM provides a comprehensive nighttime strategy that combines collagen support, cellular renewal, antioxidant defense, hydration, and barrier care in one luxurious treatment. Pair it with Collagen ReActivate AM for a complete around-the-clock collagen-focused regimen.