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★★★★★ 4.9 - Rated 4.9 out of 5 stars • Based on 17 reviews
*Rating and review count are based on customer reviews published on the manufacturer's website.*
HydroPeptide® Clear Rescue is an advanced clarifying serum designed to take a comprehensive approach to active breakouts, excess oil, congested pores, and breakout-prone skin. Formulated with 0.5% Salicylic Acid and enhanced by HydroPeptide’s signature peptide technology, Clear Rescue helps reduce blemish-causing bacteria, clear pore-clogging buildup, and support the skin’s natural defenses against visible inflammation—all while promoting a healthier skin barrier and microbiome.
Rather than treating blemishes with a single aggressive active, Clear Rescue combines a clinically proven concentration of salicylic acid with CellRenew-16, Lactobacillus Ferment Lysate, beta-glucan, aloe, sodium hyaluronate, and additional skin-supportive ingredients. This gives the serum the ability to address pre-breakout, active-breakout, and post-breakout concerns within one streamlined treatment.
Its multi-functional formula is particularly well suited for clients who want to improve clarity without sacrificing barrier health. HydroPeptide specifically identifies Clear Rescue for active breakouts, excess oil and congested pores, and all breakout-prone skin types.
Cruelty-Free • Vegan • Gluten-Free • Sulfate-Free • Phthalate-Free • Paraben-Free
Key Benefits
✔️ Helps treat existing breakouts
✔️ Helps reduce blemish-causing bacteria
✔️ Helps keep pores clear of excess oil and buildup
✔️ Supports a clearer-looking complexion
✔️ Helps address pre-, post-, and active-breakout concerns
✔️ Helps refine congested skin
✔️ Supports healthier barrier function
✔️ Helps promote microbiome resilience
✔️ Helps defend skin against visible inflammatory stress
✔️ Provides lightweight hydration
✔️ Supports overall skin resilience
✔️ Ideal for breakout-prone skin types
Key Ingredients
0.5% Salicylic Acid
Clear Rescue features a clinical-grade 0.5% concentration of salicylic acid, a beta hydroxy acid that penetrates into oily pores to help reduce buildup and support clearer-looking skin. HydroPeptide specifically highlights its role in reducing C. acnes bacteria while keeping pores free from excess oil and debris associated with new blemishes.
Benefits:
✔️ Helps treat active blemishes
✔️ Helps reduce breakout-causing bacteria
✔️ Clears pore-clogging oil and buildup
✔️ Helps prevent future congestion
✔️ Supports smoother-looking skin
CellRenew-16
HydroPeptide’s CellRenew-16 is a peptide technology designed to support several important aspects of skin health. The manufacturer states that it helps stimulate the production of growth factors associated with key structural proteins, keratins, antioxidants, and natural skin-defense mechanisms while supporting improved barrier function.
Benefits:
✔️ Supports stronger barrier function
✔️ Helps promote healthy-looking skin renewal
✔️ Supports structural proteins
✔️ Helps improve overall skin resilience
✔️ Provides age-supportive benefits within a blemish-focused formula
Lactobacillus Ferment Lysate
A microbiome-supporting ferment included to help positively influence epidermal growth while protecting the skin’s natural microbiota. HydroPeptide highlights it for helping increase resilience against stressors and inflammatory response.
Benefits:
✔️ Helps support microbiome balance
✔️ Supports healthier epidermal function
✔️ Helps improve skin resilience
✔️ Complements barrier-supportive skincare
✔️ Helps support calmer-looking skin
Sodium Hyaluronate
A form of hyaluronic acid that helps maintain moisture within the skin.
Benefits:
✔️ Provides lightweight hydration
✔️ Helps support skin comfort
✔️ Promotes smoother-looking texture
✔️ Helps balance potentially drying blemish treatments
Beta-Glucan
Beta-glucan is included to help provide soothing and barrier-supportive benefits.
Benefits:
✔️ Helps calm stressed skin
✔️ Supports hydration
✔️ Helps reinforce skin comfort
✔️ Complements the formula’s clarifying ingredients
Aloe Vera
Aloe helps provide additional soothing and hydrating support to breakout-prone skin.
Benefits:
✔️ Helps calm visible irritation
✔️ Supports skin comfort
✔️ Provides lightweight hydration
✔️ Helps balance the clarifying actives
Lilac Extract
Syringa Vulgaris (Lilac) Extract appears in the current Clear Rescue ingredient list and provides additional botanical support within the oil- and breakout-focused formula.
Benefits:
✔️ Supports balanced-looking skin
✔️ Complements oil-control strategies
✔️ Provides botanical skin-conditioning support
How to Use
Cleanse and tone the skin.
Apply a thin layer of HydroPeptide® Clear Rescue to areas experiencing active breakouts, congestion, or excess oil.
Allow the serum to absorb before applying additional serums or moisturizer.
Use consistently according to skin tolerance.
During daytime use, always finish with a broad-spectrum sunscreen.
Because Clear Rescue contains salicylic acid, avoid unnecessarily layering it in the same routine with multiple strong exfoliating products unless directed by your skincare professional.
Where It Fits in Your Routine
Clear Rescue should be used after cleansing and toning and before moisturizer.
Morning
- Cleanser
- Toner or Essence
- HydroPeptide® Clear Rescue
- Hydrating or compatible treatment serum
- Moisturizer
- Broad-Spectrum SPF
Evening
- Cleanser
- Toner or Essence
- HydroPeptide® Clear Rescue
- Compatible treatment serum, if desired
- Moisturizer
For sensitive or newly treated skin, start with fewer applications and increase gradually based on tolerance.
Ideal For
Active breakouts
Breakout-prone skin
Excess oil
Congested pores
Blackheads
Whiteheads
Uneven texture
Post-breakout skin
Combination skin
Oily skin
Individuals seeking a salicylic acid serum
Clients wanting both clarifying and barrier-supportive benefits
HydroPeptide specifically lists active breakouts, excess oil and congested pores, and all breakout-prone skin types as the primary concerns for Clear Rescue.
Professional Insight
Breakout-prone skin is often treated too aggressively. While exfoliating acids can be extremely effective, repeated use of harsh or overly drying products can compromise the barrier and leave the complexion irritated, dehydrated, or increasingly reactive.
HydroPeptide® Clear Rescue is especially interesting because it approaches blemishes from both the breakout side and the skin-health side.
The formula begins with 0.5% Salicylic Acid, which helps penetrate oily pores and break down the excess oil and buildup associated with congestion. HydroPeptide also specifically highlights salicylic acid’s ability to reduce C. acnes, one of the bacteria associated with active breakouts.
That provides the immediate clarifying component.
But instead of stopping there, HydroPeptide incorporates CellRenew-16, which helps support structural proteins, keratins, antioxidants, and natural skin-defense mechanisms. This gives the product a barrier-conscious dimension that is often missing from traditional acne-focused treatments.
The addition of Lactobacillus Ferment Lysate is particularly important for clients concerned with microbiome health. Breakout-prone skin can become increasingly reactive when the skin’s microbial ecosystem is disrupted. HydroPeptide includes this ferment to help protect the microbiota while increasing skin resilience against environmental stressors and inflammatory response.
Supporting ingredients such as Sodium Hyaluronate, Beta-Glucan, Aloe, Tocopheryl Acetate, Lilac Extract, and peptides help keep the formula from becoming a one-dimensional acne treatment.
This combination makes Clear Rescue especially useful for individuals who experience the full breakout cycle:
Before a blemish appears, salicylic acid helps keep pores clearer.
During an active breakout, the formula helps reduce blemish-causing bacteria and congestion.
Afterward, barrier and microbiome support can help maintain healthier-looking skin as the complexion recovers.
That multi-stage approach is what makes Clear Rescue stand out from a simple salicylic acid spot treatment.
For clients using a professional skincare regimen, Clear Rescue can also be paired strategically with gentle cleansers, hydrating serums, and barrier-supportive moisturizers so that breakout correction does not come at the expense of long-term skin health.
Professional Recommendation
HydroPeptide® Clear Rescue is especially beneficial for:
✔️ Active breakouts
✔️ Breakout-prone skin
✔️ Oily skin
✔️ Combination skin
✔️ Congested pores
✔️ Blackheads and whiteheads
✔️ Excess oil production
✔️ Individuals seeking a salicylic acid treatment
✔️ Clients who want clarifying benefits without ignoring barrier health
✔️ Individuals seeking microbiome-supportive blemish care
✔️ Pre-, active-, and post-breakout skincare
Formulation Highlights
✔️ 0.5% Salicylic Acid
✔️ CellRenew-16
✔️ Lactobacillus Ferment Lysate
✔️ Sodium Hyaluronate
✔️ Beta-Glucan
✔️ Aloe Vera
✔️ Tocopheryl Acetate
✔️ Lilac Extract
✔️ Myristoyl Tetrapeptide-13
✔️ Myristoyl Pentapeptide-16
✔️ Clarifying + Barrier-Supportive Formula
✔️ Microbiome-Supportive Technology
✔️ Helps Reduce Breakout-Causing Bacteria
✔️ Helps Clear Pore Buildup
✔️ Cruelty-Free
✔️ Vegan
✔️ Gluten-Free
✔️ Sulfate-Free
✔️ Phthalate-Free
✔️ Paraben-Free
With consistent use, HydroPeptide® Clear Rescue helps promote clearer, smoother, more balanced-looking skin through a sophisticated combination of 0.5% Salicylic Acid, CellRenew-16 peptide technology, Lactobacillus Ferment Lysate, hydrating ingredients, and barrier-supportive actives.
For clients dealing with active blemishes, excess oil, clogged pores, or recurring congestion, Clear Rescue offers more than traditional blemish control. By combining clarifying action with microbiome and barrier support, it provides a more complete approach to maintaining clearer-looking skin without losing sight of long-term skin health.

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