Epicutis - Lipid Serum

Epicutis® Lipid Serum is a luxurious, ultra-minimalist treatment serum designed to help calm inflammation, reduce visible redness, deeply hydrate, strengthen the skin barrier, and support healthier, more resilient skin.

Formulated with only eight carefully selected ingredients, Lipid Serum is centered around TSC (Tetramethyl Hexadecenyl Succinoyl Cysteine), Epicutis' patented, next-generation lipid technology developed to address inflammation and compromised barrier function while supporting long-term skin health.

TSC acts as what Epicutis describes as a “super-lipid,” helping restore the skin's natural barrier while targeting key inflammatory pathways. Its lipid-like properties allow the serum to absorb quickly into the skin, helping deliver calming and hydrating ingredients while supporting the skin at a deeper level.

The silky, lightweight formula also combines Sodium Hyaluronate, Propanediol, Pentylene Glycol, and Glycerin to provide immediate hydration, improve visible plumpness, and help reduce moisture loss.

Lipid Serum is especially beneficial for inflamed, stressed, sensitive, dry, compromised, or post-procedure skin, but its ability to support barrier health and reduce inflammation makes it an exceptional daily serum for virtually anyone focused on long-term skin health.

Size: 1 oz / 30 mL

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Key Benefits

✔️ Helps calm visible redness and inflammation

✔️ Supports compromised or stressed skin

✔️ Helps strengthen and restore the skin barrier

✔️ Provides immediate hydration

✔️ Helps maintain long-lasting moisture

✔️ Helps improve visible skin resilience

✔️ Supports healthier-looking skin over time

✔️ Helps protect against collagen breakdown

✔️ Helps soothe sensitive and reactive skin

✔️ Supports post-procedure recovery

✔️ Helps improve visible skin smoothness

✔️ Promotes softer, more supple-looking skin

✔️ Helps reduce transepidermal water loss

✔️ Supports a balanced skin environment

✔️ Features patented TSC Technology

✔️ Lightweight, silky texture

✔️ Fast-absorbing formula

✔️ Appropriate for sensitive and compromised skin

✔️ Ideal for morning and evening use

✔️ Formulated with only 8 ingredients

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Key Ingredients & Technologies

TSC

Tetramethyl Hexadecenyl Succinoyl Cysteine

At the center of Epicutis® Lipid Serum is TSC, a patented, next-generation molecule developed by Signum Biosciences.

Epicutis describes TSC as a “super-lipid” because of its ability to help restore the skin's natural barrier while simultaneously targeting key inflammatory pathways.

Unlike many conventional corrective skincare ingredients that rely on exfoliation or irritation to create visible change, TSC is designed to support healthier skin function without intentionally irritating or compromising the barrier.

Its lipid-like properties also allow it to absorb efficiently, making it especially valuable for stressed, inflamed, sensitive, or compromised skin.

Benefits:

✔️ Helps calm inflammation

✔️ Helps visibly reduce redness

✔️ Supports healthy barrier function

✔️ Helps restore compromised skin

✔️ Supports healthier, more resilient skin

✔️ Helps protect against collagen breakdown

✔️ Helps improve overall skin health

✔️ Supports sensitive and reactive skin

✔️ Ideal for post-procedure skin

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Sodium Hyaluronate

Hyaluronic Acid

Sodium Hyaluronate, the sodium salt of Hyaluronic Acid, provides powerful humectant hydration within Lipid Serum.

Its ability to bind water helps replenish moisture, visibly plump the skin, and soften the appearance of dehydration-related fine lines.

It also creates a lightweight moisture-supportive film that helps reduce water loss while maintaining a soft, comfortable skin feel.

Benefits:

✔️ Provides immediate hydration

✔️ Helps bind moisture to the skin

✔️ Supports visible plumpness

✔️ Helps smooth dehydration lines

✔️ Supports healthier barrier function

✔️ Helps reduce moisture loss

✔️ Promotes softer, more supple-looking skin

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Propanediol

Plant-Derived Humectant

Propanediol is a corn-derived humectant and solvent that helps increase hydration while supporting the elegant, lightweight texture of Lipid Serum.

It also helps enhance ingredient delivery and contributes to the serum's smooth, non-sticky finish.

Benefits:

✔️ Helps attract moisture

✔️ Supports skin hydration

✔️ Helps improve visible plumpness

✔️ Supports the skin barrier

✔️ Helps improve ingredient delivery

✔️ Creates a lightweight, comfortable skin feel

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Pentylene Glycol

Pentylene Glycol is a plant-derived humectant that helps attract moisture while supporting hydration, texture, and ingredient delivery.

Its multifunctional properties allow it to provide hydration without creating a heavy or greasy feel.

Benefits:

✔️ Helps attract and retain moisture

✔️ Supports skin hydration

✔️ Helps improve skin softness

✔️ Supports ingredient delivery

✔️ Helps maintain skin comfort

✔️ Appropriate for sensitive skin

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Glycerin

Glycerin is one of skincare's most proven humectants and plays an important role in the Lipid Serum's hydration system.

It attracts water to the skin and helps maintain moisture while also contributing to the serum's silky application.

Benefits:

✔️ Attracts moisture to the skin

✔️ Supports long-lasting hydration

✔️ Helps improve softness

✔️ Supports healthy barrier function

✔️ Helps prevent excessive moisture loss

✔️ Promotes a smoother skin feel

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Calm + Hydrate + Strengthen

The philosophy behind Epicutis® Lipid Serum is refreshingly simple.

Instead of overwhelming the skin with numerous active ingredients, Epicutis uses a highly streamlined formula to address three fundamental components of healthy skin:

CALM

TSC helps target key inflammatory pathways and supports visibly calmer, less reactive-looking skin.

HYDRATE

Sodium Hyaluronate, Glycerin, Propanediol, and Pentylene Glycol help replenish and maintain essential moisture.

STRENGTHEN

TSC helps support restoration of the natural skin barrier, promoting healthier, more resilient skin over time.

This combination makes Lipid Serum particularly valuable when the goal isn't simply to correct a surface concern, but to improve the overall condition and function of the skin.

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How to Use

Apply a pea-sized amount of Epicutis® Lipid Serum to clean fingertips.

Gently spread evenly over the face until completely absorbed.

For the neck and décolleté, use an additional drop.

For optimal results, use morning and evening.

Because of its lightweight texture and barrier-supportive formula, Lipid Serum can easily be incorporated into both simple and advanced skincare regimens.

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Where It Fits in Your Routine

Morning

1. Cleanser
2. Epicutis® Lipid Serum
3. Arctigenin Brightening Treatment, if desired
4. Hyvia® Crème
5. Broad-Spectrum SPF

Evening

1. Cleanser
2. Epicutis® Lipid Serum
3. Arctigenin Brightening Treatment, if desired
4. Hyvia® Crème

Within the Epicutis Simple System, Lipid Serum serves as the primary TREAT step between cleansing and hydration.

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Ideal For

Sensitive skin

Reactive skin

Visible redness

Inflamed skin

Dry skin

Dehydrated skin

Compromised skin barrier

Environmentally stressed skin

Post-procedure skin

Skin experiencing irritation

Clients using corrective skincare treatments

Individuals experiencing barrier disruption

Individuals seeking intensive hydration

Clients wanting a minimalist skincare routine

Individuals focused on long-term skin health

Clients seeking healthier, more resilient-looking skin

All skin types

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Professional Insight

Epicutis® Lipid Serum is one of those products that challenges the idea that an effective serum needs a long list of active ingredients.

There are only eight ingredients in the entire formula.

That simplicity is intentional.

Rather than loading the serum with multiple acids, retinoids, antioxidants, peptides, botanical extracts, and other competing actives, Epicutis built the formula around one sophisticated patented technology:

TSC.

TSC is the ingredient that makes Lipid Serum fundamentally different.

It was developed by Signum Biosciences, a biotechnology company with more than 20 years of research focused on novel technologies for skin health.

TSC is designed to behave like a lipid within the skin while targeting key pathways associated with inflammation.

That's an important distinction because inflammation and barrier dysfunction can contribute to a wide range of visible skin concerns.

Redness.

Sensitivity.

Dehydration.

Poor recovery.

Rough texture.

Reactive skin.

Visible signs of premature aging.

Instead of trying to address each of these concerns individually with another active ingredient, Epicutis takes a more foundational approach:

Improve the environment of the skin itself.

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Why TSC Makes This Serum Different

The hero technology in Lipid Serum is unquestionably TSC — Tetramethyl Hexadecenyl Succinoyl Cysteine.

Epicutis refers to TSC as a super-lipid.

The reason is important.

Lipids are fundamental components of a healthy skin barrier. When that barrier becomes compromised, the skin can lose moisture more easily and become increasingly susceptible to irritation and environmental stress.

TSC is designed to help restore the natural barrier while simultaneously targeting inflammatory pathways.

That combination makes it especially compelling because it isn't simply:

A hydration ingredient.

Or:

A calming ingredient.

Or:

A barrier ingredient.

It addresses several interconnected elements of skin health simultaneously.

And because TSC has lipid-like properties, it can absorb quickly while carrying a network of calming nutrients beneath the skin's surface.

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Why Inflammation Matters

Inflammation isn't always obvious.

Sometimes it presents as visible redness or irritation.

But skin can also experience low-level inflammatory stress from:

Environmental exposure

UV exposure

Aggressive skincare

Over-exfoliation

Professional treatments

Barrier disruption

Dryness

Pollution

Other everyday stressors

Over time, chronic inflammatory stress can affect the way skin looks and functions.

That's why Epicutis doesn't position Lipid Serum simply as a redness serum.

Its broader objective is to help calm inflammation while supporting healthier, more resilient skin over time.

This makes the product relevant not only for visibly sensitive skin but also for clients who simply want to protect and maintain the long-term health of their complexion.

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Exceptional for Compromised + Post-Procedure Skin

One of our favorite uses for Epicutis® Lipid Serum is when the skin needs support rather than more correction.

After certain professional aesthetic treatments, the instinct can sometimes be to return to an aggressive skincare routine too quickly.

But post-procedure skin often needs something very different:

Calm.

Hydration.

Barrier support.

Minimal ingredients.

Lipid Serum checks all four boxes.

Epicutis specifically includes Lipid Serum within its Post-Procedure Care collection, and its combination of TSC and humectant hydration makes it particularly well suited to skin experiencing temporary sensitivity or barrier disruption.

Of course, after any medical or professional procedure, follow the specific post-care instructions provided by your physician or skincare professional.

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Eight Ingredients — That's It

One of the most impressive characteristics of Lipid Serum is what isn't in the formula.

The complete ingredient list consists of only:

Water

Propanediol

Pentylene Glycol

Glycerin

Sodium Hyaluronate

Disodium Tetramethylhexadecenyl Succinoyl Cysteine (TSC)

Sodium Phytate

Citric Acid

That's the entire formula.

For clients with sensitive, reactive, compromised, or easily overwhelmed skin, that type of formulation discipline can be incredibly valuable.

Rather than asking the skin to manage dozens of ingredients, Epicutis focuses on a concise group selected to hydrate, calm, support, and strengthen.

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An Excellent Foundation for Corrective Skincare

Another reason we like Lipid Serum is that it doesn't necessarily compete with a more advanced skincare regimen.

It can provide the supportive foundation underneath it.

For example, someone targeting hyperpigmentation may use Epicutis Arctigenin Brightening Treatment after Lipid Serum.

Someone focused primarily on hydration and barrier health may follow it with Hyvia® Crème.

Someone using stronger corrective ingredients elsewhere in their regimen may benefit from having a simple, calming serum that isn't adding yet another aggressive active.

This is where Lipid Serum can become particularly useful.

Sometimes the smartest addition to an advanced skincare routine isn't another exfoliant, acid, or retinoid.

Sometimes it's the product that helps the skin better tolerate everything else you're asking it to do.

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Professional Recommendation

Epicutis® Lipid Serum is especially beneficial for:

✔️ Sensitive skin

✔️ Reactive skin

✔️ Visible redness

✔️ Inflamed or stressed skin

✔️ Dry or dehydrated skin

✔️ Compromised skin barriers

✔️ Post-procedure skin

✔️ Environmentally stressed skin

✔️ Clients experiencing irritation from corrective skincare

✔️ Individuals using retinoids or exfoliating treatments

✔️ Clients seeking barrier support

✔️ Individuals wanting intensive hydration without heaviness

✔️ Clients seeking a minimalist skincare formula

✔️ Individuals focused on long-term skin health

✔️ Clients looking to improve skin resilience

✔️ Individuals wanting a calming foundation beneath corrective treatments

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Formulation Highlights

✔️ Patented TSC Technology

✔️ Tetramethyl Hexadecenyl Succinoyl Cysteine

✔️ Next-Generation “Super-Lipid”

✔️ Barrier-Supportive Technology

✔️ Anti-Inflammatory Support

✔️ Sodium Hyaluronate

✔️ Hyaluronic Acid Hydration

✔️ Propanediol

✔️ Pentylene Glycol

✔️ Glycerin

✔️ Intensive Hydration Support

✔️ Visible Redness Support

✔️ Sensitive Skin Support

✔️ Post-Procedure Friendly

✔️ Fast-Absorbing

✔️ Silky, Lightweight Texture

✔️ Morning + Evening Use

✔️ Only 8 Ingredients

✔️ Minimalist Formulation

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Epicutis® Lipid Serum represents a different philosophy in advanced skincare: do more for the skin with less in the formula.

With only eight ingredients and therapeutic concentrations of patented TSC Technology, this silky serum helps address some of the most fundamental elements of healthy-looking skin—inflammation, hydration, barrier integrity, and resilience.

For clients experiencing redness, sensitivity, dehydration, barrier disruption, environmental stress, or post-procedure skin, Lipid Serum provides sophisticated support without overwhelming the complexion with unnecessary ingredients. And for clients whose skin is already healthy, it can serve as an exceptional daily foundation for maintaining that health over time.

Rather than aggressively forcing change at the surface, Epicutis® Lipid Serum focuses on helping the skin function better—calmer, stronger, more hydrated, and more resilient.