Epicutis - Hydrobiome Mist

Epicutis® Hydrobiome Mist is an advanced daily treatment mist designed to balance the skin's microbiome, deliver immediate hydration, calm visible irritation, strengthen the skin barrier, and provide antioxidant protection against environmental stressors.

Developed around the latest advances in microbiome-focused skincare, Hydrobiome Mist combines postbiotics, prebiotics, botanical ingredients, humectants, and powerful antioxidants in an exceptionally streamlined 12-ingredient formula.

At the center of the formula is Lactobacillus Ferment, a postbiotic that works alongside prebiotic Maltodextrin to help support a healthy environment for the beneficial microorganisms that naturally live on the skin. This combination helps promote microbiome balance while supporting the skin's natural defenses.

The formula also features Activated Grape Seed Extract (AGSE), an advanced antioxidant technology that Epicutis reports provides antioxidant protection significantly stronger than Vitamin C. Hinoki Wood Oil provides antimicrobial and soothing benefits, while Glucosylrutin helps calm inflammation and defend the skin against oxidative stress associated with UV and blue-light exposure.

Hydrating ingredients including Glycerin, Propanediol, and Pentylene Glycol help attract and retain moisture, leaving the complexion feeling refreshed, comfortable, and hydrated without heaviness.

Lightweight enough to use morning and evening—or throughout the day whenever skin needs additional hydration—Hydrobiome Mist is an easy addition to virtually any skincare routine.

Size: 1.7 oz / 50 mL

12-Ingredient Formula

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Key Benefits

Helps balance the skin's microbiome

Provides immediate lightweight hydration

Helps strengthen the skin barrier

Helps calm visible redness and irritation

Supports beneficial skin microorganisms

Helps reinforce the skin's natural defense system

Provides powerful antioxidant protection

Helps protect against environmental oxidative stress

Helps defend skin against UV-related free-radical damage

Helps protect against blue-light-related oxidative stress

Helps support antimicrobial peptides within the skin

Provides antimicrobial support

Helps improve skin resilience

Supports sensitive and reactive skin

Helps maintain moisture throughout the day

Helps reduce the feeling of dryness or tightness

Lightweight, non-heavy mist

Can be used morning and evening

Can be reapplied throughout the day as needed

Only 12 carefully selected ingredients

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Key Ingredients & Technologies

Lactobacillus Ferment

Postbiotic Microbiome Support

Lactobacillus Ferment is a postbiotic and one of the key ingredients that differentiates Hydrobiome Mist from a conventional hydrating facial spray.

Rather than simply adding moisture to the surface of the skin, Lactobacillus Ferment is included to help support a healthier, more balanced skin microbiome.

The skin's microbiome is an ecosystem of microorganisms living on the skin's surface. Maintaining an appropriate balance within this ecosystem is increasingly recognized as an important component of overall skin health.

When that balance becomes disrupted, skin may become more vulnerable to concerns such as dryness, sensitivity, visible redness, irritation, and blemishes.

Lactobacillus Ferment works alongside Maltodextrin and Hinoki Wood Oil to help promote microbial balance while supporting the skin's natural barrier and defenses.

Benefits:

Helps balance the skin microbiome

Supports beneficial microorganisms

Helps calm visible irritation

Supports healthy barrier function

Helps strengthen the skin's natural defenses

Supports healthier, more resilient-looking skin

Particularly beneficial for stressed or sensitive skin

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Maltodextrin

Prebiotic Support

Maltodextrin serves as the prebiotic component of Hydrobiome Mist's microbiome-focused system.

Prebiotics essentially provide support for beneficial microorganisms, helping create an environment in which healthy skin flora can thrive.

By pairing a prebiotic with a postbiotic, Hydrobiome Mist takes a more comprehensive approach to supporting microbiome balance.

Benefits:

Provides support for beneficial microorganisms

Helps promote microbiome balance

Complements Lactobacillus Ferment

Supports the skin's natural ecosystem

Helps maintain healthier-looking skin

Supports overall barrier health

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AGSE

Activated Grape Seed Extract

Activated Grape Seed Extract (AGSE) provides Hydrobiome Mist with powerful antioxidant protection.

Epicutis describes AGSE as a novel grape seed extract with strong antioxidant and anti-inflammatory properties designed to help calm skin and defend against visible signs associated with environmental stress.

The brand reports that the antioxidant protection provided by AGSE is six times stronger than Vitamin C, making this much more than a basic hydrating mist.

Benefits:

Provides powerful antioxidant protection

Helps neutralize damaging free radicals

Helps calm visible inflammation

Supports protection against environmental stress

Helps defend against oxidative damage

Supports healthier-looking skin

Helps fight visible signs associated with environmental aging

Complements the formula's microbiome-supporting ingredients

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Hinoki Wood Oil

Chamaecyparis Obtusa Wood Oil

Hinoki Wood Oil is derived from Japanese Hinoki cypress and provides antimicrobial, soothing, antioxidant, and barrier-supporting benefits.

Within Hydrobiome Mist, Hinoki Wood Oil plays an especially interesting role because microbiome health isn't simply about encouraging beneficial microorganisms—it is also about maintaining an appropriately balanced skin environment.

Hinoki Wood Oil helps provide antimicrobial support while simultaneously helping calm irritation and support barrier repair.

Benefits:

Provides antimicrobial support

Helps soothe visible irritation

Helps calm stressed skin

Supports barrier repair

Provides antioxidant benefits

Supports microbiome balance

Particularly beneficial for sensitive or blemish-prone skin

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Glucosylrutin

Antioxidant + Environmental Defense

Glucosylrutin is a highly water-soluble derivative of rutin, a naturally occurring flavonoid found in botanical sources including buckwheat and citrus.

It provides powerful antioxidant and anti-inflammatory benefits and helps neutralize free radicals associated with environmental exposure.

Within Hydrobiome Mist, Glucosylrutin is particularly important for helping protect the skin against oxidative stress associated with UV and blue-light exposure.

Benefits:

Provides antioxidant protection

Helps neutralize UV-induced free radicals

Helps defend against blue-light-related oxidative stress

Helps calm visible inflammation

Supports sensitive skin

Helps reinforce the skin's natural defense system

Supports healthier-looking skin

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Glycerin

Long-Lasting Humectant Hydration

Glycerin is a powerful humectant that attracts moisture to the skin and helps maintain hydration.

Rather than creating temporary surface wetness, Glycerin helps establish a moisture reservoir that supports skin hydration and barrier function.

Benefits:

Attracts moisture to the skin

Helps maintain lasting hydration

Supports the moisture barrier

Helps improve skin softness

Helps relieve feelings of dryness and tightness

Supports dry, sensitive, and compromised skin

Helps improve visible plumpness

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Propanediol

Hydration + Skin Conditioning

Propanediol provides additional humectant support while helping create the lightweight, elegant feel of Hydrobiome Mist.

It helps attract moisture to the skin without creating a heavy or sticky finish.

Benefits:

Boosts hydration

Helps smooth skin texture

Supports the skin barrier

Provides lightweight moisture

Helps improve ingredient delivery

Supports a comfortable, non-sticky finish

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Pentylene Glycol

Hydration + Antimicrobial Support

Pentylene Glycol is another multifunctional ingredient within the formula.

It acts as a humectant to help attract moisture while also providing antimicrobial properties and supporting ingredient delivery.

Benefits:

Helps attract and retain moisture

Supports hydration

Provides antimicrobial support

Helps maintain formulation stability

Supports ingredient delivery

Helps maintain a lightweight skin feel

Appropriate for sensitive skin

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Balance + Hydrate + Calm + Protect

Hydrobiome Mist isn't designed to be simply another facial water.

Its formula takes a four-part approach to supporting healthier skin:

BALANCE

Lactobacillus Ferment + Maltodextrin + Hinoki Wood Oil work together to help support a balanced skin microbiome and healthier skin ecosystem.

HYDRATE

Glycerin + Propanediol + Pentylene Glycol provide immediate lightweight hydration and help maintain the skin's moisture balance.

CALM

Lactobacillus Ferment, Hinoki Wood Oil, AGSE, and Glucosylrutin help support skin experiencing visible redness, sensitivity, or environmental stress.

PROTECT

AGSE + Glucosylrutin provide antioxidant support to help defend against free radicals and environmental oxidative stress.

The result is a mist designed to leave skin feeling hydrated, comfortable, calm, balanced, and refreshed.

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How to Use

Shake well before use.

Apply 2–3 sprays of Epicutis® Hydrobiome Mist to evenly coat the:

Face

Neck

Décolleté

Allow the mist to settle naturally onto the skin.

Use twice daily or as needed to help support a healthy microbiome and maintain hydration.

Because of its lightweight mist format, Hydrobiome Mist can also be reapplied throughout the day whenever skin feels dry, tight, stressed, or in need of refreshing hydration.

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Where It Fits in Your Routine

Hydrobiome Mist is a flexible treatment that can easily be incorporated into an existing skincare regimen.

Morning

1. Cleanse
2. Epicutis® Hydrobiome Mist
3. Treatment Serum
4. Moisturizer
5. Broad-Spectrum SPF

Evening

1. Cleanse
2. Epicutis® Hydrobiome Mist
3. Treatment Serum
4. Moisturizer

Throughout the Day

Apply 2–3 sprays as needed whenever skin needs additional hydration or refreshing.

When incorporating Hydrobiome Mist into an Epicutis regimen, it can be used after cleansing and before your leave-on treatment products.

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Ideal For

Dry skin

Dehydrated skin

Sensitive skin

Reactive skin

Combination skin

Oily skin

Blemish-prone skin

Visible redness

Compromised skin barrier

Environmentally stressed skin

Skin experiencing dryness or tightness

Individuals focused on microbiome health

Clients experiencing skin imbalance

Clients using intensive skincare regimens

Individuals seeking lightweight hydration

Clients wanting antioxidant protection

Individuals exposed to environmental stressors

Clients who spend significant time around screens

Clients wanting hydration throughout the day

Individuals seeking a microbiome-focused skincare routine

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Professional Insight

Epicutis® Hydrobiome Mist is different from a traditional facial mist because hydration is only one part of what the formula is designed to accomplish.

Many facial mists are essentially designed to make the skin feel refreshed.

There's nothing wrong with that, but Hydrobiome Mist takes the concept considerably further by focusing on something we're learning more about in professional skincare:

The skin microbiome.

Our skin isn't a sterile surface.

It's home to a complex ecosystem of microorganisms that interact with the skin and play a role in maintaining normal barrier function and overall skin health.

When that ecosystem is balanced, it helps support the skin's natural defenses.

When the balance becomes disrupted—whether from over-cleansing, aggressive skincare, environmental stress, or other factors—the skin may become more vulnerable to dryness, sensitivity, irritation, redness, and other visible signs of imbalance.

That's why we like the approach behind Hydrobiome Mist.

Instead of simply spraying water and humectants onto the skin, Epicutis combines:

A postbiotic.

A prebiotic.

Botanical antimicrobial support.

Advanced antioxidants.

Humectant hydration.

It's a much more comprehensive approach to what a facial mist can accomplish.

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Prebiotic + Postbiotic Skincare

Two terms you'll increasingly see in professional skincare are prebiotics and postbiotics.

They sound similar, but they serve different purposes.

PREBIOTIC

Think of a prebiotic as support for beneficial microorganisms.

In Hydrobiome Mist, Maltodextrin provides prebiotic support that helps create a favorable environment for beneficial microbes.

POSTBIOTIC

A postbiotic is made up of beneficial compounds associated with microorganisms rather than introducing live bacteria to the formula.

In Hydrobiome Mist, Lactobacillus Ferment provides postbiotic support.

Putting the two together creates a more sophisticated microbiome-focused strategy.

Rather than attempting to simply add bacteria to the skin, the formula is designed to support the environment in which the skin's natural microbiome exists.

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Why Microbiome Balance Matters

The microbiome can be thought of as another component of the skin's natural protective system.

A balanced microbiome helps support:

Barrier function.

Normal inflammatory responses.

Defense against undesirable microorganisms.

Moisture balance.

Overall skin resilience.

When the microbiome becomes disrupted, the skin can become more vulnerable.

That doesn't mean every instance of dryness, redness, or blemishes is caused by microbiome imbalance.

Skin is much more complicated than that.

But maintaining a healthy microbiome is increasingly recognized as an important part of maintaining healthy skin.

That's what makes Hydrobiome Mist particularly interesting.

It's not attempting to aggressively correct the skin.

It's designed to support the environment healthy skin needs to function properly.

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More Than Microbiome Support

While microbiome balance is the headline benefit, Hydrobiome Mist isn't a one-dimensional product.

The formula also delivers meaningful antioxidant protection.

That's where AGSE + Glucosylrutin become important.

Activated Grape Seed Extract provides powerful antioxidant and anti-inflammatory support.

Glucosylrutin helps neutralize UV-induced free radicals while helping protect against oxidative stress and environmental exposure.

This gives Hydrobiome Mist another important function:

Environmental defense.

So every time the product is applied, you're not simply refreshing the skin.

You're providing:

Microbiome support.

Hydration.

Antioxidant protection.

Soothing support.

Barrier support.

That's a very different proposition from an ordinary facial mist.

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Excellent for Stressed or Over-Treated Skin

Hydrobiome Mist can be particularly appealing for clients whose skin has become overwhelmed by an overly aggressive skincare routine.

Many people continuously add:

Retinoids.

Acids.

Exfoliating pads.

Scrubs.

Brightening treatments.

Corrective serums.

Peels.

Eventually, the skin may begin feeling:

Dry.

Tight.

Sensitive.

Reactive.

Uncomfortable.

Visibly red.

When that happens, adding another aggressive corrective ingredient may not be what the skin needs.

Sometimes the better strategy is to focus on hydration, barrier health, calming support, and balance.

Hydrobiome Mist fits beautifully into that type of routine.

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Excellent for Daily Hydration

One of the easiest ways to use Hydrobiome Mist is also the simplest:

Keep it nearby and use it whenever your skin needs hydration.

Morning after cleansing.

Evening before your serum.

Midday when skin feels dry.

After spending hours in air conditioning.

After traveling.

After a long flight.

After spending time outdoors.

Whenever skin simply feels like it needs a refresh.

Because the formula combines humectants with microbiome-supporting and antioxidant ingredients, each application provides more than temporary surface hydration.

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A Great Partner for Lipid Serum + Hyvia® Crème

Hydrobiome Mist also pairs beautifully with two of Epicutis' signature products:

Lipid Serum

and

Hyvia® Crème.

The three products approach skin health from complementary directions.

Hydrobiome Mist

BALANCE + HYDRATE

Supports the microbiome, provides antioxidant defense, and delivers lightweight hydration.

Lipid Serum

TREAT

Provides targeted barrier and calming support while delivering concentrated hydration.

Hyvia® Crème

HYDRATE + SEAL

Provides richer moisture, lipids, ceramides, and antioxidant support to help strengthen the barrier and maintain hydration.

Layered together, they create a sophisticated routine focused on:

Microbiome balance.

Hydration.

Barrier health.

Calming support.

Environmental protection.

Long-term skin resilience.

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Only 12 Ingredients

Another standout feature of Hydrobiome Mist is its remarkably focused formula.

The entire product contains only 12 ingredients:

Water

Propanediol

Pentylene Glycol

Glycerin

PPG-13-Decyltetradeceth-24

Chamaecyparis Obtusa Wood Oil

Vitis Vinifera (Grape) Seed Extract

Lactobacillus Ferment

Maltodextrin

Glucosylrutin

Sodium Phytate

Citric Acid

Rather than filling the formula with an unnecessarily long list of ingredients, Hydrobiome Mist centers on a concise combination of postbiotic support, prebiotic support, antioxidant protection, botanical antimicrobial support, and humectant hydration.

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Professional Recommendation

Epicutis® Hydrobiome Mist is especially beneficial for:

Microbiome balance

Dry skin

Dehydrated skin

Sensitive skin

Reactive skin

Visible redness

Compromised skin barriers

Environmentally stressed skin

Skin experiencing dryness or tightness

Blemish-prone skin

Individuals using aggressive corrective skincare

Clients focused on barrier health

Individuals seeking antioxidant protection

Clients exposed to environmental stressors

Individuals seeking blue-light-related antioxidant defense

Clients wanting lightweight daily hydration

Individuals who frequently travel

Clients wanting a midday skin refresh

Lipid Serum users

Hyvia® Crème users

Individuals building a microbiome-focused skincare regimen

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Formulation Highlights

Microbiome-Balancing Treatment Mist

1.7 oz / 50 mL

Only 12 Ingredients

Lactobacillus Ferment Postbiotic

Maltodextrin Prebiotic

Activated Grape Seed Extract — AGSE

Hinoki Wood Oil

Glucosylrutin

Glycerin

Propanediol

Pentylene Glycol

Prebiotic + Postbiotic Support

Microbiome Balance

Intensive Lightweight Hydration

Barrier Support

Antioxidant Protection

Visible Redness Support

Soothing Support

Antimicrobial Support

Environmental Defense

UV-Related Oxidative Stress Support

Blue-Light-Related Oxidative Stress Support

Sensitive Skin Friendly

Morning + Evening Use

Can Be Reapplied Throughout the Day

BALANCE + HYDRATE + CALM + PROTECT

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Epicutis® Hydrobiome Mist elevates the traditional facial mist into a true daily skincare treatment. By combining Lactobacillus Ferment, prebiotic Maltodextrin, Activated Grape Seed Extract, Hinoki Wood Oil, Glucosylrutin, Glycerin, Propanediol, and Pentylene Glycol, the formula simultaneously addresses microbiome balance, hydration, visible inflammation, barrier health, and environmental protection.

For clients experiencing dehydration, sensitivity, visible redness, environmental stress, barrier disruption, or simply wanting to better support the skin's natural ecosystem, Hydrobiome Mist provides an exceptionally easy way to incorporate microbiome-focused skincare into an existing regimen.

With only 12 carefully selected ingredients and a lightweight mist delivery system, it can be used morning, evening, or throughout the day to leave the complexion feeling hydrated, refreshed, calm, comfortable, balanced, and supported.