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DEFEND™ HA + PDRN Serum is an advanced daily treatment designed to deeply hydrate, strengthen, and visibly renew the skin through the combination of cutting-edge regenerative technology and proven hydration science. Powered by Hyaluronic Acid and PDRN (Polydeoxyribonucleotide), this next-generation serum helps replenish moisture, support the skin's natural renewal process, strengthen the moisture barrier, and improve the appearance of firmness, elasticity, and overall skin vitality.
Unlike traditional hydrating serums that focus primarily on moisture alone, DEFEND™ HA + PDRN Serum combines intensive hydration with ingredients that help support healthier-looking, more resilient skin over time. The lightweight, fast-absorbing formula layers effortlessly beneath moisturizers, sunscreen, and makeup, making it an ideal addition to both morning and evening skincare routines.
Suitable for all skin types—including aging, dehydrated, sensitive, and post-procedure skin—DEFEND™ delivers immediate hydration while supporting long-term improvements in skin texture, radiance, and overall skin health.
Key Benefits
✔️ Provides deep, long-lasting hydration
✔️ Helps visibly plump the appearance of fine lines and wrinkles
✔️ Supports visible skin renewal and repair
✔️ Improves the appearance of skin firmness and elasticity
✔️ Strengthens the skin's natural moisture barrier
✔️ Helps reduce the appearance of dull, dehydrated skin
✔️ Promotes smoother, healthier-looking skin texture
✔️ Helps improve overall skin radiance
✔️ Lightweight, fast-absorbing formula
✔️ Layers seamlessly under moisturizer, SPF, and makeup
✔️ Suitable for all skin types
Key Ingredients
PDRN (Polydeoxyribonucleotide)
An innovative skincare ingredient recognized for supporting visible skin renewal and healthier-looking skin.
Benefits
✔️ Helps support the skin's natural repair process
✔️ Promotes a smoother, more resilient complexion
✔️ Supports healthier-looking skin over time
Hyaluronic Acid
A powerful humectant that attracts and retains moisture within the skin.
Benefits
✔️ Provides deep hydration
✔️ Helps plump the appearance of fine lines
✔️ Supports smoother, softer skin
Niacinamide
A multitasking skincare ingredient known for improving overall skin health.
Benefits
✔️ Helps improve uneven skin tone
✔️ Supports the skin's moisture barrier
✔️ Promotes healthier-looking skin clarity
Green Tea Extract
A potent botanical antioxidant that helps defend against environmental stressors.
Benefits
✔️ Provides antioxidant protection
✔️ Helps minimize oxidative stress
✔️ Supports healthier-looking skin
Aloe Vera, Cucumber & Chamomile Extracts
A soothing botanical blend that helps calm and replenish the skin.
Benefits
✔️ Helps reduce visible redness
✔️ Provides additional hydration
✔️ Supports skin comfort and balance
Phospholipids & Sphingolipids
Essential skin-identical lipids that help reinforce the skin barrier.
Benefits
✔️ Strengthen the moisture barrier
✔️ Help reduce moisture loss
✔️ Promote healthier, more resilient skin
How to Use
Cleanse and thoroughly dry the skin.
Apply 2–3 drops to the face and neck.
Gently massage until fully absorbed.
Follow with your favorite moisturizer, such as CO2Lift® Carboxy Mousse Moisturizer.
Finish with sunscreen during daytime use.
Use morning and evening for optimal results.
Professional Tip
For enhanced hydration and recovery, incorporate DEFEND™ HA + PDRN Serum into your routine following professional aesthetic treatments or pair it with CO2Lift® Pro as part of a comprehensive skin-rejuvenation regimen.
Ideal For
Dehydrated skin
Fine lines and wrinkles
Loss of firmness and elasticity
Compromised skin barrier
Dull or tired-looking skin
Sensitive skin
Post-procedure skincare support
Mature skin
Daily anti-aging routines
Anyone seeking advanced hydration and skin renewal
Professional Insight
Healthy skin depends on more than moisture alone. As we age and encounter daily environmental stressors, the skin's natural ability to repair itself, retain hydration, and maintain barrier integrity gradually declines. These changes can contribute to dehydration, loss of elasticity, rough texture, dullness, and the appearance of fine lines.
DEFEND™ HA + PDRN Serum was developed to address these concerns through a comprehensive approach that combines intensive hydration with advanced skin-supporting technology. At the heart of the formula is PDRN (Polydeoxyribonucleotide), an innovative ingredient increasingly recognized in advanced skincare for its ability to support the skin's natural renewal processes and promote a healthier, more resilient appearance.
Complementing PDRN is Hyaluronic Acid, one of the most respected hydration ingredients in dermatology. By attracting and retaining moisture within the skin, Hyaluronic Acid helps immediately replenish hydration while softening the appearance of dehydration-related fine lines and improving overall skin suppleness.
The formula is further enhanced with niacinamide to strengthen the skin barrier and improve skin tone, green tea extract to provide antioxidant protection, and soothing botanicals including aloe vera, cucumber, and chamomile to calm visible redness and irritation. Skin-identical phospholipids and sphingolipids help reinforce the moisture barrier, reducing transepidermal water loss and supporting long-term skin health.
Its lightweight, non-greasy texture makes DEFEND™ HA + PDRN Serum exceptionally versatile. It integrates easily into virtually any skincare routine, layers beautifully beneath moisturizers and sunscreen, and provides excellent hydration without feeling heavy on the skin. It is also an excellent option following aesthetic procedures, when maintaining hydration and supporting barrier recovery are especially important.
With consistent use, the skin appears smoother, firmer, brighter, and more resilient while maintaining optimal hydration and a healthier overall appearance.
Professional Recommendation
DEFEND™ HA + PDRN Serum is especially beneficial for:
✔️ Dry and dehydrated skin
✔️ Fine lines and wrinkles
✔️ Loss of firmness and elasticity
✔️ Dull, tired-looking skin
✔️ Compromised skin barrier
✔️ Sensitive skin
✔️ Post-procedure recovery
✔️ Daily anti-aging skincare routines
✔️ Anyone seeking advanced hydration with skin-renewal support
Formulation Highlights
✔️ PDRN (Polydeoxyribonucleotide)
✔️ Hyaluronic Acid
✔️ Niacinamide
✔️ Green Tea Extract
✔️ Aloe Vera, Cucumber & Chamomile
✔️ Phospholipids & Sphingolipids
✔️ Lightweight, Fast-Absorbing Formula
✔️ Barrier-Supporting Hydration
✔️ Antioxidant Protection
✔️ Professional-Grade Daily Renewal Serum
With continued use, DEFEND™ HA + PDRN Serum helps replenish hydration, strengthen the skin's natural barrier, and support healthier-looking skin through advanced renewal technology. The result is a complexion that appears smoother, firmer, brighter, and more resilient, with lasting hydration and a healthy, youthful-looking glow.
